Fenofibrat Paten

Fenofibrat Paten. The first granules may comprise fenofibrate from 03% to 10% by weight of the first granules of a first surfactant and a first water soluble or water dispersible cellulose derivative and the second granules may comprise fenofibrate from 0% to 025% by weight of the second granules of a second surfactant and a second water soluble or water.

The present invention relates to a novel galenic formulation of fenofibrate for oral administration and to the process for its preparation According to the invention the formulation is a tablet obtained by compressing a mixture comprising a) granules containing 1 to 5% of a surfactant micronized fenofibrate and at least one solid excipient selected from starch cellulose and derivatives.

Fenofibrate: Side Effects, Dosage, Uses, and More

Fenofibrate oral tablet is a medication prescribed for high cholesterol levels It’s mainly used to treat severe high triglyceride levels It&#39s available as a generic drug and as the brandname.

WO2014003706A1 Fenofibrate formulation Google Patents

How It WorksUpsidesDownsidesBottom LineTipsResponse and EffectivenessInteractionsFurther InformationFenofibrate may be used for the treatment of high cholesterolFenofibrate activates an enzyme called lipoprotein lipase which increases the breakdown of lipids and the elimination of triglyceriderich particles from the bloodFenofibrate belongs to the class of medicines called fibrates May be used to treat high cholesterol (dyslipidemia) in adults with primary hypercholesterolemia or mixed dyslipidemiaCan be a good alternative for people who can&#39t tolerate statinsShould be used in addition to a healthy dietAlso used to lower the risk of pancreatitis in adults with very high triglyceride levels (more than 2000 mg/dL) If you are between the ages of 18 and 60 take no other medication or have no other medical conditions side effects you are more likely to experience include 1 Abdominal pain a headache backache nausea constipation nasal congestion or a runny nose 2 Fenofibrate has been associated with myopathy (dysfunction of muscle fibers) and rhabdomyolysis (muscle cell destruction) The risk is increased in seniors and in people with diabetes kidney disease hypothyroidism and also in those taking statins or colchicine Tablets may need to be discontinued if serious muscle problems occur 3 Has not been shown to reduce the risk of death from heart disease in patients with type 2 diabetes 4 Dosage may need to be reduced in people with mildtomoderate kidney disease (the recommended initial dose is 54 mg/day) Not recommended for people with severe kidney disease 5 May cause an increase in liver enzymes Liver enzymes need to be periodically monitored and fenofibrate should be d Fenofibrate is effective at reducing triglyceride levels and increasing HDL cholesterol levels however it is less effective than statins at reducing LDL cholesterol levels Fenofibrate tablets sh Can be given with or without foodUse in addition to an appropriate lipidlowering diet and regular exercise Reducing body weight and alcohol consumption will also help lower cholesterol and triglyceride levelsReport promptly any unexplained muscle tenderness weakness or pain especially if other symptoms (such as fever or feeling unwell) are also presentSeek urgent medical attention if you develop symptoms of an allergic reaction (such as difficulty breathing swelling or a rash) or yellowing of the skin or eyes while taking fenofibrate Fenofibrate is quickly absorbed and converted into its active ingredient fenofibric acid once inside the body Takes about a week for levels to stabilize May take several weeks before effects on cFenofibrate lowers total cholesterol by 9 to 13% VLDL cholesterol by 44 to 49% triglycerides by 46 to 54% and apolipoprotein B (Apo B) Fenofibrate also increases HDL cholesterol by 1922%Cholesterol and triglyceride levels should be monitored every four to eight weeksDosage should be individualized according to the response Medicines that interact with fenofibrate may either decrease its effect affect how long it works for increase side effects or have less of an effect when taken with fenofibrate An interaction between two medications does not always mean that you must stop taking one of the medications however sometimes it does Speak to your doctor about how drug interactions should be managed Common medications that may interact with fenofibrate include 1 acyclovir 2 aminoglycosides such as gentamicin or neomycin 3 betablockers such as atenolol or sotalol 4 black cohosh 5 colchicine 6 cancer medications such as cisplatin or pemetrexed 7 cholestyramine 8 cyclosporine 9 diabetes medications such as insulin glimepiride glipizide or glyburide 10 diuretics such as HCTZ or chlorthalidone 11 ezetimibe 12 leflunomide 13 other lipidlowering drugs such as atorvastatin or simvastatin 14 raltegravir 15 red yeast rice 16 ursodiol 17 warfarin Alcohol may make fenofibrate treat Remember keep this and all other medicines out of the reach of children never share your medicines with others and use fenofibrate only for the indication prescribed Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances Copyright 19962022 Drugscom Revision date May 21 2021 Medical Disclaimer.